ePoster

Background and Aim: Aberrant crypt foci (ACF) in the rectum have been reported to correlate with risk of colorectal tumorigenesis are useful biomarkers for predicting cancer because they quantitative can be evaluated a short period time. Leukotriene receptor antagonists (LTRAs) inhibitory effects on various carcinomas, but their unknown. Based report that overexpresses cysteinyl leukotriene receptor, we investigated whether LTRA medication affects number ACF. Methods: The eligibility criteria were patients who between 30 80 years old, had tumors suitable endoscopic resection, at least five ACFs rectum. First, enrolled group, treated montelukast sodium 10 mg 8 weeks, rectal counted during treatment tumors. no follow-up group as control group. Results: One patient was not examined due COVID-19 pandemic, so 9 decreased -2.4 (SD 2.2) compared baseline, while there decrease 0.4 2.3) significant difference ACF trends two groups (P = 0.002). Ki67 labeling index, which is cell proliferation activity, -1.34 2.68) it 0.13 1.89) groups. Conclusion: may reduce cancer.